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K2 Synthetic Marijuana

What is K2?

K2, also called Spice or synthetic marijuana, is dried plant material, sometimes ground potpourri, sprayed with chemicals that stimulate the cannabinoid receptors in the brain. K2 is sold in small packets, often called potpourri or incense, and carries a label that says “Not for Human Consumption.” K2 may be labeled Moon Rocks, Dead Man Walking, Crazy Clown, 3X, or other names.

Several chemicals often found in K2 are classified by the Drug Enforcement Agency as a Schedule 1 substance, which means it is illegal to buy them, sell them to others, or possess them. While many forms of synthetic marijuana chemicals are illegal, others have been altered just enough to evade the law and can still be bought in stores and online.

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What does K2 do?

K2 is often described as “natural” and a safe, legal alternative to marijuana, but the Centers for Disease Control and Prevention reported that the consumption of K2 can cause very dangerous results. When K2 is smoked, the chemicals increase heart rate, may cause hallucinations, aggressive or violent behavior, and in some cases users experience psychosis and kidney damage.

What are the risks of K2?

Because K2 is illegal and not regulated, what is sold can contain any number of harmful chemicals. K2 is much stronger than natural marijuana so the reaction in the cannabinoid receptors can be many hundreds of times more dangerous. There have been reports of seizures, heart attacks, and even suicide among people who have used K2. What is sold as K2 may also contain other chemicals or drugs that could cause harm. Since it is illegal to buy, sell, or possess K2, there are legal risks in addition to the health effects.

To learn more about K2, check out this page from the National Institute on Drug Abuse.

Synthetic Drugs

Synthetic Drugs (a.k.a. K2, Spice, Bath Salts, etc.)

  • Synthetic cannabinoids, commonly known as “synthetic marijuana,” “K2,” or “Spice”, are often sold in legal retail outlets as “herbal incense” or “potpourri”, and synthetic cathinones are often sold as “bath salts” or “jewelry cleaner”. They are labeled “not for human consumption” to mask their intended purpose and avoid Food and Drug Administration (FDA) regulatory oversight of the manufacturing process.
  • Synthetic cannabinoids are man-made chemicals that are applied (often sprayed) onto plant material and marketed as a “legal” high.  Users claim that synthetic cannabinoids mimic Δ9-tetrahydrocannabinol (THC), the primary psychoactive active ingredient in marijuana.
  • Use of synthetic cannabinoids is alarmingly high, especially among young people.  According to the 2012 Monitoring the Future survey of youth drug-use trends, one in nine 12th graders in America reported using synthetic cannabinoids in the past year.  This rate, unchanged from 2011, puts synthetic cannabinoids as the second most frequently used illegal drug among high school seniors after marijuana (see chart).
  • Synthetic cathinones are man-made chemicals related to amphetamines.  Synthetic cathinone products often consist of methylenedioxypyrovalerone (MDPV), mephedrone, and methylone.
  • The Administration has been working with Federal, Congressional, state, local, and non-governmental partners to put policies and legislation in place to combat this threat, and to educate people about the tremendous health risk posed by these substances.

Figure 1: Use of Illicit Drugs among Twelfth Graders, 2012 Monitoring the Future Study

A Rapidly Emerging Threat

  • Synthetic cannabinoids laced on plant material were first reported in the U.S. in December 2008, when a shipment of “Spice” was seized and analyzed by U.S. Customs and Border Protection (CBP) in Dayton, Ohio.
  • There is an increasingly expanding array of synthetic drugs available.  51 new synthetic cannabinoids were identified in 2012, compared to just two in 2009. Furthermore, 31 new synthetic cathinones were identified in 2012, compared to only four in 2009.  In addition, 76 other synthetic compounds were identified in 2012, bringing the total number of new synthetic substances identified in 2012 to 158.

Risk to the Public Health

  • The contents and effects of synthetic cannabinoids and cathinones are unpredictable due to a constantly changing variety of chemicals used in manufacturing processes devoid of quality controls and government regulatory oversight.
  • Health warnings have been issued by numerous public health authorities and poison control centers describing the adverse health effects associated with the use of synthetic drugs.
  • The effects of synthetic cannabinoids include severe agitation and anxiety, nausea, vomiting, tachycardia (fast, racing heartbeat), elevated blood pressure, tremors and seizures, hallucinations, dilated pupils, and suicidal and other harmful thoughts and/or actions.
  • Similar to the adverse effects of cocaine, LSD, and methamphetamine, synthetic cathinone use is associated with increased heart rate and blood pressure, chest pain, extreme paranoia, hallucinations, delusions, and violent behavior, which causes users to harm themselves or others.

Sources and Continuing Availability

  • According to CBP, many synthetic cannabinoid and cathinone products originate overseas.  Law enforcement personnel have also encountered the manufacture of synthetic drugs in the U.S., including in residential neighborhoods.
  • Synthetic drugs are often sold at small retail outlets and are readily available via the Internet.  The chemical compositions of synthetic drugs are frequently altered in an attempt to avoid government bans.

Government Efforts to Ban Synthetic Drug Products

  • Congress has taken steps to ban many of these substances at the Federal level, and the Administration has supported such efforts.
  • The Synthetic Drug Abuse Prevention Act is part of the FDA Safety and Innovation Act of 2012, signed into law by President Obama.  The law permanently places 26 types of synthetic cannabinoids and cathinones into Schedule I of the Controlled Substances Act (CSA).  It also doubled the maximum period of time that the Drug Enforcement Administration (DEA) can administratively schedule substances under its emergency scheduling authority, from 18 to 36 months.
  • The Controlled Substance Analogue Enforcement Act of 1986 allows many synthetic drugs to be treated as controlled substances if they are proven to be chemically and/or pharmacologically similar to a Schedule I or Schedule II controlled substance.
  • In 2011, DEA exercised its emergency scheduling authority to control five types of synthetic cannabinoids, and three of the synthetic substances used to manufacture synthetic cathinones.  In 2012, all but one of these substances were permanently designated as Schedule I substances under the Synthetic Drug Abuse Prevention Act, and the remaining substance was permanently placed into Schedule I by DEA regulation.
  • On April 12, 2013, DEA used its emergency scheduling authority to schedule three more types of synthetic cannabinoids, temporarily designating them as Schedule I substances.
  • At least 43 states have taken action to control one or more synthetic cannabinoids. Prior to 2010, synthetic cannabinoids were not controlled by any State or at the Federal level.  In addition, at least 44 states have taken action to control one or more synthetic cathinones.

What are synthetic cannabinoids

What are synthetic cannabinoids?

Synthetic cannabinoids are human-made mind-altering chemicals that are either sprayed on dried, shredded plant material so they can be smoked or sold as liquids to be vaporized and inhaled in e-cigarettes and other devices. These products are also known as herbal or liquid incense.

These chemicals are called cannabinoids because they are similar to chemicals found in the marijuana plant. Because of this similarity, synthetic cannabinoids are sometimes misleadingly called synthetic marijuana (or fake weed), and they are often marketed as safe, legal alternatives to that drug. In fact, they are not safe and may affect the brain much more powerfully than marijuana; their actual effects can be unpredictable and, in some cases, more dangerous or even life-threatening.

Synthetic cannabinoids are part of a group of drugs called new psychoactive substances (NPS). NPS are unregulated mind-altering substances that have become newly available on the market and are intended to produce the same effects as illegal drugs. Some of these substances may have been around for years but have reentered the market in altered chemical forms, or due to renewed popularity.

Manufacturers sell these products in colorful foil packages and plastic bottles to attract consumers. They market these products under a wide variety of specific brand names.

For several years, synthetic cannabinoid mixtures have been easy to buy in drug paraphernalia shops, novelty stores, gas stations, and over the internet. Because the chemicals used in them have no medical benefit and a high potential for abuse, authorities have made it illegal to sell, buy, or possess some of these chemicals. However, manufacturers try to sidestep these laws by changing the chemical formulas in their mixtures.

Easy access and the belief that synthetic cannabinoid products are natural and therefore harmless, have likely contributed to their use among young people. Another reason for their continued use is that standard drug tests cannot easily detect many of the chemicals used in these products.

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How do people use synthetic cannabinoids?

The most common way to use synthetic cannabinoids is to smoke the dried plant material. Users also mix the sprayed plant material with marijuana or brew it as tea. Other users buy synthetic cannabinoid products as liquids to vaporize in e-cigarettes.

How do synthetic cannabinoids affect the brain?

Synthetic cannabinoids act on the same brain cell receptors as THC (delta-9-tetrahydrocannabinol), the mind-altering ingredient in marijuana.

So far, there have been few scientific studies of the effects of synthetic cannabinoids on the human brain, but researchers do know that some of them bind more strongly than marijuana to the cell receptors affected by THC and can produce much stronger effects. The resulting health effects can be unpredictable and dangerous.

Because the chemical composition of many synthetic cannabinoid products is unknown and may change from batch to batch, these products are likely to contain substances that cause dramatically different effects than the user might expect.

Synthetic cannabinoid users report some effects similar to those produced by marijuana:

  • elevated mood
  • relaxation
  • altered perception—awareness of surrounding objects and conditions
  • symptoms of psychosis—delusional or disordered thinking detached from reality

Psychotic effects include:

  • extreme anxiety
  • confusion
  • paranoia—extreme and unreasonable distrust of others
  • hallucinations—sensations and images that seem real though they are not

What are some other health effects of synthetic cannabinoids?

People who have used synthetic cannabinoids and have been taken to emergency rooms have shown severe effects including:

  • rapid heart rate
  • vomiting
  • violent behavior
  • suicidal thoughts

Are synthetic cannabinoids addictive?

Yes, synthetic cannabinoids can be addictive. Regular users trying to quit may have the following withdrawal symptoms:

  • headaches
  • anxiety
  • depression
  • irritability

Behavioral therapies and medications have not specifically been tested for treatment of addiction to these products. Health care providers should screen patients for possible co-occurring mental health conditions.

Can you overdose on synthetic cannabinoids?

Yes. An overdose occurs when a person uses too much of a drug and has a dangerous reaction that results in serious, harmful symptoms or death. Use of synthetic cannabinoids can cause:

  • toxic reactions
  • elevated blood pressure
  • reduced blood supply to the heart
  • kidney damage
  • seizures

Deaths can also occur when dangerous synthetic opioids, such as fentanyl, are added to the packaged mixture without the user knowing it.